Our Curated Research articles:
| # | Reference / Paper / Year |
| Small extracellular vesicles from young plasma reverse age‑related functional declines by improving mitochondrial energy metabolism (2024) | Delivery of small EVs (sEVs) from young plasma to aged mice improved mitochondrial function, enhanced cellular energy, and reversed certain age‑related declines. Nature+1 |
| A bibliometric analysis of exosomes in aging from 2007 to 2023 (2025) | Systematic review of 1,628 articles mapping the role of exosomes in aging and aging‑related diseases; highlights growing scientific interest in EVs as anti‑aging / regenerative tools. PMC |
| Therapeutic Potential of Extracellular Vesicles in Aging and Age‑Related Diseases (2025) | Reviews how EVs may modulate cellular senescence, inflammation, and tissue degeneration — suggesting their potential as therapeutic agents for wellness and longevity. PMC+1 |
| Extracellular vesicles in aging: an emerging hallmark? (2023) | Proposes that alteration in EV biology is a core feature of aging; suggests modulating EV production or profile may influence aging processes. PMC+1 |
| Extracellular Vesicles for Regenerative Medicine (2022) | Reviews regenerative medicine applications of EVs — tissue repair, wound healing, organ regeneration — underscoring their versatility beyond just cell‑based therapies. MDPI+1 |
| Exosomes: A Review of Biologic Function, Diagnostic and Therapeutic Potentials (2024) | General review on exosome biology, their composition, mechanisms of action, and broad therapeutic potential — useful background reference for any exosome‑based therapy proposal. SpringerLink+1 |
What to Keep in Mind
- Many of the strong findings (especially in the “longevity” / “reversal of aging” domain) come from preclinical studies in animals (e.g. mice), not yet large-scale human trials.
- Evidence on mechanism, dosage, and long-term safety of EV therapy is still evolving.
- As with any emerging field, standardization (isolation, purity, potency, reproducibility) remains a challenge — so when you refer to these papers in your own work, be clear about limitations and difference in protocols.